ECTS
ECTS Course Catalogue
Course details
Course code: NBSS20156o12Semester: 2012/2013 summer
Name: Structure Modification of Organic Compounds
Major: Biotechnology
Study Type: second cycle
Course type: compulsory
Study Semester: 1
ECTS points: 10
Hours (Lectures / Tutorials / Other): 45 / 90 / 0
Lecturer: dr hab. Teresa Kołek prof. nadzw.
Language of instruction: Polish
Learning outcomes: Knowledge Students, after course completion, explain the use of multienzymatic transformations in the synthesis; recognize enzymes participating in these transformations; explain advantages of the use of biocatalysis in synthesis; indicate methods of modification of the biocatalyst properties; recognize factors determining the process effectiveness. Skills: Students carry out enzymatic transformations utilizing various forms of biocatalysts; prepare these biocatalysts; operate the equipment; interpret the results and calculate the catalytic activity of enzymes; design and carry out determination of selected biological properties of compounds; identify obtained metabolites.
Competences: Students cooperate with other team members when preparing and executing the experiments; they are aware that cooperation and attitudes compatible with team cooperation rules have significant impact on the smooth workflow of the whole team.
Prerequisites: Organic Chemistry, Biochemistry, Microbiology, Basics of biotransformation.
Course content: Use of enzymatic reactions in modifications of molecules of natural substrates (carbohydrates, proteins, isoprenoids, antibiotics). Enzymatic reactions of carbon-carbon bond formation. “Green chemistry” – enzymes in synthesis of biodegradable surfactants. Bioremediation as a method of disposal of environmentally persistent substances Genetic modification of microorganisms directed towards formation of an effective biocatalysts for a given transformation.
Recommended literature: 1. Biotransformations II, vol. 8a and 8b, editor D. R. Kelly, Wiley-Vch GmbH, Weinheim 2000 2. 2. Biotransformations in organic chemistry, Faber K., Springer-Verlang, Berlin, Heidenberg 2000; 3. Spectroscopic identification of organic compounds, R.M. Silverstein and G.C. Bassler, John Wiley and Sons, Inc. 1967 3. 4. Metody spektroskopowe i ich zastosowanie do identyfikacji związków organicznych, Praca zbiorowa pod redakcją W. Zielińskiego i A. Rajcy, Wydawnictwo Naukowo-Techniczne Warszawa 1995.
Assessment methods: Completion of the practicals, written reports from the practicals, colloquia, final project, written exam.
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