ECTS
ECTS Course Catalogue
Course details
Course code: BIS10026o11Semester: 2011/2012 summer
Name: INTRODUCTION TO BIOINFORMATICS
Major: Bioinformatics
Study Type: first cycle
Course type: compulsory
Study Semester: 4
ECTS points: 5
Hours (Lectures / Tutorials / Other): 15 / 30 / 0
Lecturer: dr hab. Paweł Mackiewicz
Language of instruction: Polish
Learning outcomes: Student is taught theoretical and practical principles of different bioinformatics analyses on all levels of organization of biological information. A particular emphasis is placed on the diversity of bioinformatics databases, tools and software.
Competences: After completing the course student is able to search appropriate databases and apply suitable bioinformatics software to specific problems and tasks related to analyses of biological data. Passing the course permits working in laboratories dealing with processing of biological data by computational methods (e.g. molecular and bioinformatics laboratories and companies, research and service units).
Prerequisites: Biochemistry, cell biology, informatics technologies, computer programs
Course content: Subject and levels of genomics and bioinformatics analyses. Stages of genome sequencing. Types of biological databases. Problems in the databases. Computational methods in recognition of protein coding sequences in Prokaryota and Eukaryota. Structure and organization of genomes, genome analyses, comparative genomics. Computational analyses of RNA sequences. Alignment of pair of sequences and multiple sequence alignment. Searching databases for similar sequences (FASTA and BLAST algorithms). Motifs and patterns in sequences. Computational analyses of protein sequences, analysis of basic physicochemical properties, recognition of transmemmbrane regions, motifs and domains in proteins, determination of secondary structure. Databases of structures, methods predicting tertiary structure, structural classification of proteins. Phylogenetics and molecular evolution, construction and evaluation of phylogenetic trees, phylogenomics. System biology.
Recommended literature: Baxevanis A.D., Ouellette B.F.F. Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins. Wiley-Liss, Inc. 2005 (lub wersja tłumaczona na język polski Bioinformatyka podręcznik do analizy genów i białek wydana przez PWN, 2004) Claverie J.M., NotredameC. Bioinformatics For Dummies. Wiley Publishing, Inc. 2006 Higgs P.G., Attwood T.K. Bioinformatyka i ewolucja molekularna, PWN, 2008 Hall B. Łatwe drzewa filogenetyczne. WUW, 2008 Jin X. Podstawy bioinformatyki, WUW, 2011
Assessment methods: Completion of practical lessons: practical colloquium using computer Examination in the form of open test
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